Jeremiah 21:6

Authorized King James Version

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And I will smite the inhabitants of this city, both man and beast: they shall die of a great pestilence.

Original Language Analysis

וְהִכֵּיתִ֗י And I will smite H5221
וְהִכֵּיתִ֗י And I will smite
Strong's: H5221
Word #: 1 of 12
to strike (lightly or severely, literally or figuratively)
אֶת H853
אֶת
Strong's: H853
Word #: 2 of 12
properly, self (but generally used to point out more definitely the object of a verb or preposition, even or namely)
יֽוֹשְׁבֵי֙ the inhabitants H3427
יֽוֹשְׁבֵי֙ the inhabitants
Strong's: H3427
Word #: 3 of 12
properly, to sit down (specifically as judge. in ambush, in quiet); by implication, to dwell, to remain; causatively, to settle, to marry
הָעִ֣יר of this city H5892
הָעִ֣יר of this city
Strong's: H5892
Word #: 4 of 12
a city (a place guarded by waking or a watch) in the widest sense (even of a mere encampment or post)
הַזֹּ֔את H2063
הַזֹּ֔את
Strong's: H2063
Word #: 5 of 12
this (often used adverb)
וְאֶת H853
וְאֶת
Strong's: H853
Word #: 6 of 12
properly, self (but generally used to point out more definitely the object of a verb or preposition, even or namely)
הָאָדָ֖ם both man H120
הָאָדָ֖ם both man
Strong's: H120
Word #: 7 of 12
ruddy i.e., a human being (an individual or the species, mankind, etc.)
וְאֶת H853
וְאֶת
Strong's: H853
Word #: 8 of 12
properly, self (but generally used to point out more definitely the object of a verb or preposition, even or namely)
הַבְּהֵמָ֑ה and beast H929
הַבְּהֵמָ֑ה and beast
Strong's: H929
Word #: 9 of 12
properly, a dumb beast; especially any large quadruped or animal (often collective)
בְּדֶ֥בֶר pestilence H1698
בְּדֶ֥בֶר pestilence
Strong's: H1698
Word #: 10 of 12
a pestilence
גָּד֖וֹל of a great H1419
גָּד֖וֹל of a great
Strong's: H1419
Word #: 11 of 12
great (in any sense); hence, older; also insolent
יָמֻֽתוּ׃ they shall die H4191
יָמֻֽתוּ׃ they shall die
Strong's: H4191
Word #: 12 of 12
to die (literally or figuratively); causatively, to kill

Cross References

Isaiah 6:11Then said I, Lord, how long? And he answered, Until the cities be wasted without inhabitant, and the houses without man, and the land be utterly desolate,Jeremiah 33:12Thus saith the LORD of hosts; Again in this place, which is desolate without man and without beast, and in all the cities thereof, shall be an habitation of shepherds causing their flocks to lie down.Jeremiah 32:24Behold the mounts, they are come unto the city to take it; and the city is given into the hand of the Chaldeans, that fight against it, because of the sword, and of the famine, and of the pestilence: and what thou hast spoken is come to pass; and, behold, thou seest it.Ezekiel 14:17Or if I bring a sword upon that land, and say, Sword, go through the land; so that I cut off man and beast from it:Ezekiel 14:13Son of man, when the land sinneth against me by trespassing grievously, then will I stretch out mine hand upon it, and will break the staff of the bread thereof, and will send famine upon it, and will cut off man and beast from it:Ezekiel 14:19Or if I send a pestilence into that land, and pour out my fury upon it in blood, to cut off from it man and beast:Ezekiel 14:21For thus saith the Lord GOD; How much more when I send my four sore judgments upon Jerusalem, the sword, and the famine, and the noisome beast, and the pestilence, to cut off from it man and beast?Hosea 4:3Therefore shall the land mourn, and every one that dwelleth therein shall languish, with the beasts of the field, and with the fowls of heaven; yea, the fishes of the sea also shall be taken away.Zephaniah 1:3I will consume man and beast; I will consume the fowls of the heaven, and the fishes of the sea, and the stumblingblocks with the wicked; and I will cut off man from off the land, saith the LORD.

Analysis & Commentary

And I will smite the inhabitants of this city, both man and beast: they shall die of a great pestilence—God declares He will personally strike (hikketi, הִכֵּיתִי, from nakah, נָכָה) Jerusalem's population. The comprehensive nature ('both man and beast,' me'adam ve'ad behemah, מֵאָדָם וְעַד־בְּהֵמָה) echoes the plague language of Exodus, but now directed at God's own people rather than Egypt. They shall die of a great pestilence (dever gadol, דֶּבֶר גָּדוֹל, great plague/pestilence) refers to epidemic disease, one of three judgment forms consistently prophesied: sword, famine, and pestilence (Jeremiah 14:12, 21:9, 24:10).

The inclusion of animals emphasizes total devastation—not merely human casualties but ecological collapse. This fulfills covenant curses of Leviticus 26:22, Deuteronomy 28:21. The 'great pestilence' resulted from siege conditions: starvation, contaminated water, disease from unburied corpses, and lack of sanitation in the crowded, besieged city. Lamentations 4:9-10 describes the horror: 'Better are those slain with the sword than those slain with hunger... compassionate women have boiled their own children.' The tragedy is that this suffering was preventable—God had offered terms of survival through surrender (Jeremiah 21:8-9), but Judah's leaders rejected God's word. The judgment shows that rebellion against God brings death and destruction, while repentance and obedience bring life (Deuteronomy 30:15-20).

Historical Context

The siege of Jerusalem (588-586 BC) created catastrophic conditions documented in biblical and archaeological sources. Lamentations provides eyewitness accounts of starvation (Lamentations 2:11-12, 4:4-5), cannibalism (Lamentations 4:10), and disease. Second Kings 25:3 states 'the famine prevailed in the city, and there was no bread for the people of the land.' Josephus (Jewish Antiquities 10.7.3) describes similar conditions during the Roman siege in 70 AD, likely reflecting traditions about the Babylonian siege. Excavations at Jerusalem's Stepped Stone Structure and City of David reveal burnt layers, arrowheads, and mass burial sites from this period. The 'pestilence' would have included dysentery, typhoid, and other diseases spread by poor sanitation, contaminated water, and malnutrition. Ancient siege warfare deliberately created these conditions to break a city's will to resist. The fulfillment of Jeremiah's specific prophecy of sword, famine, and pestilence vindicated his authenticity as God's prophet.

Questions for Reflection

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